Iman Osman

BRAF mutation predicts sensitivity to MEK inhibition

David B. Solit, Levi A. Garraway, Christine A. Pratilas et al. · Nature · 2005 · 1.3K citations · Full text

Signal Transduction, Braf Mutation, Genetic Disorder +6

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

Luping Lin, Amit J. Sabnis, Elton Chan et al. · Nature Genetics · 2015 · 548 citations · Full text

Medicine, Mek-targeted Cancer Therapies, Hippo Effector Yap +8

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor

Miguel F. Segura, Douglas Hanniford, Sílvia Menéndez et al. · Proceedings of the National Academy of Sciences · 2009 · 541 citations · Full text

Melanoma Cell Lines, Tumor Biology, Systems Biology +12

Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment

Dalia Barkley, Reuben Moncada, Maayan Pour et al. · Nature Genetics · 2022 · 492 citations · Full text

Tumor Heterogeneity, Medicine, Biological Microenvironments +11

Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

Douglas Hanniford, Alejandro Ulloa‐Morales, Alcida Karz et al. · Cancer Cell · 2020 · 411 citations · Full text

Epigenetic Silencing, Medicine, Melanoma +5