PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

Xinming Cai, YongYao Xu, Atwood K. Cheung, +21

Chemistry & Biology

InflammationCytokineSignal TransductionSignaling PathwayReceptor Tyrosine Kinase +6

Structure of the Substrate Binding Domain of the Thermosome, an Archaeal Group II Chaperonin

Martin Klumpp, Wolfgang Baumeister, Lars‐Oliver Essen

Cell

BiochemistryProtein AssemblyNatural SciencesStructural BioinformaticsProtein X-ray Crystallography +5

Group II chaperonin in an open conformation examined by electron tomography

Michael Nitsch, Jochen Walz, Dieter Typke, +3

Nature Structural Biology

BiophysicsProtein FoldingNatural SciencesElectron TomographyMolecular Biology +8

Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor

Christine Gräf, Martin Klumpp, Michael Habig, +5

Molecular Pharmacology

Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach

Chao Chen, Hugh Zhu, Frédéric Stauffer, +14

ACS Medicinal Chemistry Letters

Drug TargetMolecular BiologyChemical BiologyPharmaceutical ChemistryRecruit Dot1l +18

The thermosome: alternating α and β-subunits within the chaperonin of the archaeon Thermoplasma acidophilum

Michael Nitsch, Martin Klumpp, Andrei N. Lupas, +1

Journal of Molecular Biology

BiologyUnicellular OrganismAlternating αProkaryotic SystemBiochemistry +9

A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products

Anne Mai Wassermann, Eugen Lounkine, László Urbán, +8

ACS Chemical Biology

Drug TargetHit IdentificationDrug ScreeningMedicinal ChemistryBioanalysis +17

Readout Technologies for Highly Miniaturized Kinase Assays Applicable to High-Throughput Screening in a 1536-Well Format

Martin Klumpp, Andreas Boettcher, Damaris Becker, +6

SLAS DISCOVERY

Analysis of p53 “Latency” and “Activation” by Fluorescence Correlation Spectroscopy

Julian Wölcke, Maurice Reimann, Martin Klumpp, +3

Journal of Biological Chemistry

Measurement of enzyme kinetics and inhibitor constants using enthalpy arrays

Michael I. Recht, Frank E. Torres, Dirk De Bruyker, +3

Analytical Biochemistry

Enzyme KineticsChemical MeasurementEngineeringBiochemistryDifferential Scanning Calorimetry +8