Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents

Peng‐Cheng Lv, Huan‐Qiu Li, Juan Sun, +2

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicineDrug DiscoveryPyrazole DerivativesPharmacological Agent +8

Inhibiting aerobic glycolysis suppresses renal interstitial fibroblast activation and renal fibrosis

Hao Ding, Lei Jiang, Jing Xu, +6

American Journal of Physiology-Renal Physiology

Renal PathologyRenal InflammationRenal FibrosisOxidative StressInflammation +20

Sodium–glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice

Ting Cai, Qingqing Ke, Yi Fang, +11

Cell Death and Disease

Sodium–glucose Cotransporter 2Diabetic MiceRenal InflammationKidney SamplesKidney Tubule Cells +23

Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts

Tingting Li, Yuting Zhuang, Wanqi Yang, +12

The FASEB Journal

Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis

Yu Zhang, Ping Wen, Jing Luo, +7

Cell Death and Disease

Urinary MicroRNA-10a and MicroRNA-30d Serve as Novel, Sensitive and Specific Biomarkers for Kidney Injury

Nan Wang, Yang Zhou, Lei Jiang, +4

PLoS ONE

Renal PathologyImmunologyRenal InflammationPathologyKidney Injury +18

A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-β1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis

Lei Jiang, Wenjing Qiu, Yang Zhou, +8

Kidney International

Rheb/mTORC1 Signaling Promotes Kidney Fibroblast Activation and Fibrosis

Lei Jiang, Lingling Xu, Junhua Mao, +8

Journal of the American Society of Nephrology

Renal PathologyImmunologyRenal InflammationRapamycin Complex 1Nephrology +16

PDE/cAMP/Epac/C/EBP-β Signaling Cascade Regulates Mitochondria Biogenesis of Tubular Epithelial Cells in Renal Fibrosis

Hao Ding, Feng Bai, Hongdi Cao, +11

Antioxidants and Redox Signaling

METTL3 boosts mitochondrial fission and induces cardiac fibrosis by enhancing LncRNA GAS5 methylation

Bin Tu, Kai Song, Yang Zhou, +11

Pharmacological Research