Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the <i>Acanthocheilonema viteae</i> Product ES-62 Prevents Development of Collagen-Induced Arthritis

Lamyaa Al‐Riyami, Miguel A. Pineda, Justyna Rzepecka, +7

Journal of Medicinal Chemistry

InflammationRheumatologyNew Anti-inflammatory DrugsAnti-inflammatoryAutoimmune Disease +12

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

L.B. Tulloch, Viviane Paula Martini, J. Iulek, +6

Journal of Medicinal Chemistry

Bioorganic ChemistryAntiparasitic AgentPharmacotherapyDhfr InhibitorsChemical Biology +15

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

Justyna Rzepecka, Miguel A. Pineda, Lamyaa Al‐Riyami, +10

Journal of Autoimmunity

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

Abedawn I. Khalaf, Judith K. Huggan, Colin J. Suckling, +7

Journal of Medicinal Chemistry

Diversity oriented syntheses of fused pyrimidines designed as potential antifolates

Colin L. Gibson, Judith K. Huggan, Alan R. Kennedy, +7

Organic & Biomolecular Chemistry

Combinatorial ChemistryBioorganic ChemistryOrganic ChemistryChemistryHeterocycle Chemistry +16

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Justyna Rzepecka, Michelle L. Coates, Moninder Saggar, +10

International Journal for Parasitology

Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers

Nahoum G. Anthony, Jessica Baiget, Giacomo Berretta, +21

Journal of Medicinal Chemistry

ImmunologySelective InhibitorsU2os CellsInflammationMolecular Pharmacology +16

Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT

Rachel L. Clark, Carol Clements, Michael P. Barrett, +5

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryQuinazoline-2,4-dione ScaffoldsMedicineSubmicromolar Inhibitors +5

6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases

Colin J. Suckling, Colin L. Gibson, Judith K. Huggan, +6

Bioorganic & Medicinal Chemistry Letters

Bioorganic ChemistryBiochemistryReactive Nitrogen SpecieNatural SciencesNitric Oxide Synthases +2

Diversity oriented synthesis: substitution at C5 in unreactive pyrimidines by Claisen rearrangement and reactivity in nucleophilic substitution at C2 and C4 in pteridines and pyrido[2,3-d]pyrimidines

Jonathan Adcock, Colin L. Gibson, Judith K. Huggan, +1

Tetrahedron

Diversity Oriented SynthesisEngineeringUnreactive PyrimidinesClaisen RearrangementNatural Sciences +8