Judith K. Huggan

Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the <i>Acanthocheilonema viteae</i> Product ES-62 Prevents Development of Collagen-Induced Arthritis

Lamyaa Al‐Riyami, Miguel A. Pineda, Justyna Rzepecka et al. · Journal of Medicinal Chemistry · 2013 · 91 citations

Inflammation, Rheumatology, New Anti-inflammatory Drugs +14

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

L.B. Tulloch, Viviane Paula Martini, J. Iulek et al. · Journal of Medicinal Chemistry · 2009 · 86 citations · Full text

Bioorganic Chemistry, Antiparasitic Agent, Pharmacotherapy +17

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

Justyna Rzepecka, Miguel A. Pineda, Lamyaa Al‐Riyami et al. · Journal of Autoimmunity · 2015 · 77 citations · Full text

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

Abedawn I. Khalaf, Judith K. Huggan, Colin J. Suckling et al. · Journal of Medicinal Chemistry · 2014 · 52 citations · Full text

Diversity oriented syntheses of fused pyrimidines designed as potential antifolates

Colin L. Gibson, Judith K. Huggan, Alan R. Kennedy et al. · Organic & Biomolecular Chemistry · 2009 · 42 citations

Combinatorial Chemistry, Bioorganic Chemistry, Organic Chemistry +18