Jonathan L. Chen

Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

Hafeez S. Haniff, Yuquan Tong, Xiaohui Liu et al. · ACS Central Science · 2020 · 205 citations · Full text

Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model

Alicia J. Angelbello, Suzanne G. Rzuczek, Kendra McKee et al. · Proceedings of the National Academy of Sciences · 2019 · 120 citations · Full text

Designer Small Molecule, Molecular Biology, Lead Chemical Probes +16

Testing the Nearest Neighbor Model for Canonical RNA Base Pairs: Revision of GU Parameters

Jonathan L. Chen, Abigael L. Dishler, Scott D. Kennedy et al. · Biochemistry · 2012 · 86 citations · Full text

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

Jonathan L. Chen, Peiyuan Zhang, Masahito Abe et al. · Journal of the American Chemical Society · 2020 · 78 citations · Full text

Analogue Synthesis, Molecular Biology, Lead Identification +19

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G ₄ C ₂ ) repeat expansion in vitro and in vivo ALS models

Jessica A. Bush, Haruo Aikawa, Rita Fuerst et al. · Science Translational Medicine · 2021 · 76 citations · Full text