Miriam de Groote

Thiazole and Thiadiazole Analogues as a Novel Class of Adenosine Receptor Antagonists

Jacqueline E. van Muijlwijk‐Koezen, H. Timmerman, Roeland C. Vollinga et al. · Journal of Medicinal Chemistry · 2001 · 147 citations · Full text

Isoquinoline and Quinazoline Urea Analogues as Antagonists for the Human Adenosine A₃Receptor

Jacqueline E. van Muijlwijk‐Koezen, Henk Timmerman, H. van der Goot et al. · Journal of Medicinal Chemistry · 2000 · 122 citations · Full text

Potent antagonists for the human adenosine A2B receptor. Derivatives of the triazolotriazine adenosine receptor antagonist ZM241385 with high affinity

Maarten de Zwart, Roel C. Vollinga, Margot W. Beukers et al. · Drug Development Research · 1999 · 55 citations

Cyclic Amp Response, Molecular Pharmacology, Medicinal Chemistry +15

Differential effects of the allosteric enhancer (2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone (PD81,723) on agonist and antagonist binding and function at the human wild-type and a mutant (T277A) adenosine A1 receptor11Abbreviations: CCPA, 2-chloro-N6-cyclopentyladenosine; DPCPX, 1,3-dipropyl-8-cyclopentylxanthine; CPA, N6-cyclopentyladenosine, R-PIA, N6-[-(R)-1-methyl-2-phenylethyl]adenosine; NECA, 5′-(N-ethyl)-carboxamidoadenosine; N-0840, N6-cyclopentyl-9-methyladenine; theophylline, 1,3-dimethylxanthine; PD81,723, (2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone; BCA, bicinchoninic acid; BCS, bovine calf serum; cAMP, adenosine 3′,5′-cyclic monophosphate; DMEM, Dulbecco’s modified Eagle’s medium; CHO, Chinese hamster ovary; and wt, wild-type.

Angeliki P. Kourounakis, Corine C. Visser, Miriam de Groote et al. · Biochemical Pharmacology · 2001 · 49 citations

2,5‘-Disubstituted Adenosine Derivatives:  Evaluation of Selectivity and Efficacy for the Adenosine A₁, A_2A, and A₃ Receptor

Erica W. van Tilburg, Jacobien von Frijtag Drabbe Künzel, Miriam de Groote et al. · Journal of Medicinal Chemistry · 2001 · 44 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Adenosine Derivatives +12