Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

Susan P.C. Cole, Gabu Bhardwaj, James H. Gerlach, +7

Science

Gene AmplificationTumor MicroenvironmentOncogenic AgentMedicineTransporter Gene +13

Doxorubicin Activates ATM-dependent Phosphorylation of Multiple Downstream Targets in Part through the Generation of Reactive Oxygen Species

Ebba U. Kurz, Pauline Douglas, Susan P. Lees‐Miller

Journal of Biological Chemistry

Lipid PeroxidationReactive Oxygen SpeciesRedox BiologyTumor BiologyOxidative Stress +22

Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis

Sarah Hewitt, Jaclyn I. Wamsteeker, Ebba U. Kurz, +1

Nature Neuroscience

Altered Chloride HomeostasisSynaptic PlasticityMolecular PhysiologySignal TransductionSynaptic Inhibitory Constraint +10

Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines.

Marilyn L. Slovak, Jennifer Pelkey Ho, Gabu Bhardwaj, +3

PubMed

Molecular BiologyCancer BiologyMrp GeneTumor BiologyMrp Mrna +14

Response of Cultured Maize Cells to (+)-Abscisic Acid, (-)-Abscisic Acid, and Their Metabolites

John Balsevich, Adrian J. Cutler, Nancy Lamb, +4

PLANT PHYSIOLOGY

Plant PhysiologyEngineeringPlant MetabolomicsBiosynthesisCell Surface +17

Analysis of the Intron–Exon Organization of the Human Multidrug-Resistance Protein Gene (MRP) and Alternative Splicing of Its mRNA

Caroline E. Grant, Ebba U. Kurz, Susan P.C. Cole, +1

Genomics

Natural SciencesGeneticsProtein GeneticsMolecular BiologyMolecular Genetics +7

The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX

Ruiqiong Ye, Aaron A. Goodarzi, Ebba U. Kurz, +6

DNA repair

Reductive StressSystems BiologyMolecular RegulationMedicineGenetics +8

The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase II alpha expression and confers hypersensitivity to etoposide in human leukemic cell lines.

Ebba U. Kurz, Steven E. Wilson, Kelly B. Leader, +4

PubMed

Chemoprevention StrategyEpigenetic ChangeConfers HypersensitivityCell DeathEtoposide Sensitization +20

Identification of DNA–Protein Interactions in the 5′ Flanking and 5′ Untranslated Regions of the Human Multidrug Resistance Protein (MRP1) Gene: Evaluation of a Putative Antioxidant Response Element/AP-1 Binding Site

Ebba U. Kurz, Susan P.C. Cole, Roger G. Deeley

Biochemical and Biophysical Research Communications

Redox SignalingDna–protein InteractionsUntranslated RegionsBiochemistryMedicine +8

M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma

Alexandra Pisklakova, Brienne McKenzie, Franz J. Zemp, +9

Neuro-Oncology