Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of  -synuclein in Parkinson's disease models

Michaeline Hebron, Irina Lonskaya, Charbel Moussa

Human Molecular Genetics

Cell DeathDopamine NeuronsSynaptic SignalingBrain AccumulationCell Autophagy +21

Regulation of Poly(ADP-ribose) Polymerase-1 by DNA Structure-specific Binding

Irina Lonskaya, Vladimir N. Potaman, Luda S. Shlyakhtenko, +3

Journal of Biological Chemistry

Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance

Irina Lonskaya, Michaeline Hebron, Nicole M. Desforges, +2

Journal of Molecular Medicine

Cell AutophagyAlzheimer's DiseaseMolecular NeuroscienceAutophagyCell Death +8

Tyrosine kinase inhibition increases functional parkin‐ <scp>B</scp> eclin‐1 interaction and enhances amyloid clearance and cognitive performance

Irina Lonskaya, Michaeline Hebron, Nicole M. Desforges, +2

EMBO Molecular Medicine

Cell DeathSynaptic SignalingSocial SciencesNeuroinflammationAlzheimer's Disease +17

Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)

Michaeline Hebron, Irina Lonskaya, Kaydee Sharpe, +4

Journal of Biological Chemistry

Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA

Olga Timofeeva, Sergey Chasovskikh, Irina Lonskaya, +10

Journal of Biological Chemistry

Diminished Parkin Solubility and Co-Localization with Intraneuronal Amyloid-β are Associated with Autophagic Defects in Alzheimer's Disease

Irina Lonskaya, Ashot R. Shekoyan, Michaeline Hebron, +3

Journal of Alzheimer s Disease

Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer’s disease models

Irina Lonskaya, Michaeline Hebron, S. Selby, +2

Neuroscience

ImmunologyNeurochemical BiomarkersAlzheimer ’Social SciencesNeuroinflammation +17

Ubiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance

Irina Lonskaya, Nicole M. Desforges, Michaeline Hebron, +1

PLoS ONE

MitophagyCell DeathParkin ActivitySynaptic SignalingSocial Sciences +20

Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies

Xiaoguang Liu, Michaeline Hebron, Wangke Shi, +2

Human Molecular Genetics

MitophagyUsp13 LevelsProteasomeMolecular BiologyAlpha-synuclein Clearance +15