D N Burnham

Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst.

J. David Lambeth, D N Burnham, S R Tyagi · Journal of Biological Chemistry · 1988 · 118 citations · Full text

Life Sciences, Biochemistry, Cell Biology +13

Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.

S R Tyagi, Minoru Tamura, D N Burnham et al. · Journal of Biological Chemistry · 1988 · 101 citations · Full text

Life Sciences, Biochemistry, Cell Biology +13

Cyclic AMP-elevating agents block chemoattractant activation of diradylglycerol generation by inhibiting phospholipase D activation

S R Tyagi, Susan C. Olson, D N Burnham et al. · Journal of Biological Chemistry · 1991 · 77 citations · Full text

Life Sciences, Cell Biology, Pharmacology +16

Diradylglycerol synergizes with an anionic amphiphile to activate superoxide generation and phosphorylation of p47phox in a cell-free system from human neutrophils.

D N Burnham, David J. Uhlinger, J. David Lambeth · Journal of Biological Chemistry · 1990 · 67 citations · Full text

Life Sciences, Biochemistry, Cell Biology +13

On the Biological Occurrence and Regulation of 1-Acyl and 1-O-Alkyl-diradylglycerols in Human Neutrophils

S R Tyagi, D N Burnham, J. David Lambeth · Journal of Biological Chemistry · 1989 · 58 citations · Full text

Life Sciences, Molecular Biology, Enzymology +13