Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases

Stephen Claridge, Franck Raeppel, Marie‐Claude Granger, +23

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryVegfr2 Tyrosine KinasesMedicineNatural Sciences +9

Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors

Ljubomir Isakovic, Oscar M. Saavedra, David B. Llewellyn, +13

Bioorganic & Medicinal Chemistry Letters

Dna Methyltransferase InhibitorsMedicinal ChemistryBiochemistryNatural SciencesOligonucleotide +2

N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors

Michael R. Mannion, Stéphane Raeppel, Stephen Claridge, +20

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetNovel SeriesBiochemistryMedicine +10

SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes

Oscar M. Saavedra, Ljubomir Isakovic, David B. Llewellyn, +13

Bioorganic & Medicinal Chemistry Letters

BiochemistryNatural SciencesEpigenetic ChangeDna MethylationEpigenomics +5

Probing the importance of spacial and conformational domains in captopril analogs for angiotensin converting enzyme activity

Stephen Hanessian, Ulrich Reinhold, Michel Saulnier, +1

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineNatural SciencesPharmacology +10

The Power of Visual Imagery in Synthesis Planning. Stereocontrolled Approaches to CGP-60536B, a Potent Renin Inhibitor

Stephen Hanessian, Stephen Claridge, Shawn Johnstone

The Journal of Organic Chemistry

N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors

Stéphane Raeppel, Stephen Claridge, Oscar Saavedra, +20

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetNovel SeriesBiochemistryMedicine +9

A diastereoselective synthesis of benzopyrans using a novel intramolecular Nicholas reaction in the key cyclisation step

John M. Berge, Stephen Claridge, Alastair Mann, +2

Tetrahedron Letters

EngineeringHeterocyclicDiastereoselective SynthesisKey Cyclisation StepOrganic Chemistry +5

N3-Arylmalonamides: A new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases

Oscar Saavedra, Stephen Claridge, Lijie Zhan, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryVegfr2 Tyrosine KinasesMedicineRational Drug DesignPharmacological Agent +7

Identification of a novel series of potent RON receptor tyrosine kinase inhibitors

Stéphane Raeppel, Frédéric Gaudette, Michael R. Mannion, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetNovel SeriesBiochemistryMedicine +7