Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy

Gregory M. Chen, Changya Chen, Rajat K. Das, +11

Cancer Discovery

Developmental trajectory of prehematopoietic stem cell formation from endothelium

Qin Zhu, Peng Gao, Joanna Tober, +10

Blood

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in <i>KMT2A</i>-rearranged leukemia

Changya Chen, Wenbao Yu, Fatemeh Alikarami‬, +22

Blood

Mixed-phenotype Acute LeukemiaGeneticsImmunologyLeukemia CellsSingle-cell Multiomics Reveals +17

Identifying noncoding risk variants using disease-relevant gene regulatory networks

Long Gao, Yasin Uzun, Peng Gao, +5

Nature Communications

scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data

Wenbao Yu, Yasin Uzun, Qin Zhu, +2

Genome biology

IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment

Irina Elcheva, Chethana P. Gowda, Daniel Bogush, +9

Frontiers in Immunology

Epigenetic state determines inflammatory sensing in neuroblastoma

Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, +15

Proceedings of the National Academy of Sciences

Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells

Peng Gao, Changya Chen, Elizabeth D. Howell, +9

Genes & Development

Hsc OntogenyTranscriptomics TechnologyGene Regulatory NetworkEpigeneticsTranscriptional Regulation +15

Risk variants disrupting enhancers of T _H 1 and T _REG cells in type 1 diabetes

Peng Gao, Yasin Uzun, Bing He, +4

Proceedings of the National Academy of Sciences

Identification and Characterization of Chemotherapy-Resistant High-Risk Neuroblastoma Persister Cells

Liron D. Grossmann, Chia-Hui Chen, Yasin Uzun, +36

Cancer Discovery