AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer

Hong Zhu, Linlin Chang, Fangjie Yan, +8

Theranostics

The USTC co-opts an ancient machinery to drive piRNA transcription in <i>C. elegans</i>

Chenchun Weng, Ahmet C. Berkyurek, Przemysław Stempor, +12

Genes & Development

Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R–YAP Axis

Hong Zhu, Dandan Wang, Tao Yuan, +15

Cancer Research

Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation

Chenming Zeng, Chenchun Weng, Xiaoyang Wang, +9

Cell Reports

Germ granule compartments coordinate specialized small RNA production

Xiangyang Chen, Ke Wang, Farees Ud Din Mufti, +12

Nature Communications

A chromodomain protein mediates heterochromatin-directed piRNA expression

Xinya Huang, Peng Cheng, Chenchun Weng, +7

Proceedings of the National Academy of Sciences

The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer

Hong Zhu, Yan Hu, Chenming Zeng, +11

Theranostics

Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism

Chenming Zeng, Difeng Zhu, Jun You, +4

Frontiers in Physiology

Hormonal ContraceptiveAldo-keto ReductasePharmacotherapyExperimental PharmacologyMolecular Pharmacology +14

AKR1C1 connects autophagy and oxidative stress by interacting with SQSTM1 in a catalytic-independent manner

Linlin Chang, Yue-Kang Li, Chenxi Zhao, +8

Acta Pharmacologica Sinica

Cell AutophagyMitophagyBiochemistryNatural SciencesAutophagy +8

Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity

Tao Yuan, Chenming Zeng, Jiawei Liu, +15

Signal Transduction and Targeted Therapy