Gerald S. Shadel

Mitochondrial DNA stress primes the antiviral innate immune response

A. Phillip West, William Khoury-Hanold, Matthew Staron et al. · Nature · 2015 · 1.8K citations · Full text

Inflammation, Autoimmune Disease, Mitochondrial Function +8

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

A. Phillip West, Igor E. Brodsky, Christoph Rahner et al. · Nature · 2011 · 1.6K citations · Full text

Inflammation, Toll-like Receptors, Innate Immune System +7

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

Anthony Rongvaux, Ruaidhrí Jackson, Christian C. D. Harman et al. · Cell · 2014 · 799 citations · Full text

Apoptotic Caspases Prevent, Mitochondrial Function, Mitochondrial Dynamic +8

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Hongxu Xian, Kosuke Watari, Elsa Sánchez‐López et al. · Immunity · 2022 · 642 citations · Full text

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

Michal Caspi Tal, Miwa Sasai, Heung Kyu Lee et al. · Proceedings of the National Academy of Sciences · 2009 · 561 citations · Full text

Mitophagy, Autophagy Manifest, Autophagy Results +19