Formation of Cyclic Sulfinates and Sulfinamides through Homolytic Substitution at the Sulfur Atom

J Coulomb, Victor Certal, Louis Fensterbank, +2

Angewandte Chemie International Edition

EngineeringOrganic ChemistryStereogenic Sulfur AtomChemistryHeterocycle Chemistry +14

Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers

Victor Certal, Jean‐Christophe Carry, Frank Halley, +33

Journal of Medicinal Chemistry

Compound 28New SeriesChemical BiologyPharmaceutical ChemistryPi3kβ Inhibitors +16

Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3<i>S</i>)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7<i>H</i>-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer

Youssef El‐Ahmad, Michel Tabart, Frank Halley, +37

Journal of Medicinal Chemistry

Intramolecular Homolytic Substitution of Sulfinates and Sulfinamides

J Coulomb, Victor Certal, Marie‐Hélène Larraufie, +6

Chemistry - A European Journal

SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models

Maysoun Shomali, Jane Cheng, Fangxian Sun, +27

Molecular Cancer Therapeutics

Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3Kβ Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers

Victor Certal, Frank Halley, Angéla Virone-Oddos, +24

Journal of Medicinal Chemistry

Single Pi3kTumor Growth DelayKinase InhibitorsPharmacotherapyPharmaceutical Chemistry +19

Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-<i>c</i>]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone

François Vallée, Chantal Carrez, Fabienne Pilorge, +23

Journal of Medicinal Chemistry

A Major Breakthrough in the Use of Alkoxycarbene Complexes of Chromium and Tungsten for the Synthesis of Elaborate Organic Compounds: Dihydropyridine Induced Reductions and Cascade Insertion Reactions

H. Rudler, A. Parlier, Thomas F. Durand-Réville, +5

Tetrahedron

Alkoxycarbene ComplexesChemical EngineeringEngineeringElaborate OrganicCoordination Complex +5

Linear Coupling of Three CO Ligands of Chromium Hexacarbonyl Leading to Functionalized Butenolides via Fischer Carbene Complexes

H. Rudler, Andrée Parlier, Victor Certal, +1

Angewandte Chemie International Edition

Inorganic ChemistryChemical EngineeringCross-coupling ReactionEngineeringCarbene Complexes +11

Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3Kβ inhibitors

Victor Certal, Frank Halley, Angéla Virone-Oddos, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDerivativesBiochemistryMedicineNatural Sciences +6