Lynsey Shaffer

Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors

Brian M. Lacey, Zangwei Xu, Xiaomei Chai et al. · SLAS DISCOVERY · 2020 · 28 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +13

Establishment of a 96-well transwell system using primary human gut organoids to capture multiple quantitative pathway readouts

Charles Wright, Naomi Li, Lynsey Shaffer et al. · Scientific Reports · 2023 · 27 citations · Full text

Life Sciences, Cell Biology, Oncology +17

The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3<i>R</i>,4<i>S</i>)-4-cyanotetrahydro-2<i>H</i>-pyran-3-yl)-1<i>H</i>-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties

Tony Siu, Jason D. Brubaker, Peter H. Fuller et al. · Journal of Medicinal Chemistry · 2017 · 18 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability

Joey L. Methot, Hua Zhou, Solomon D. Kattar et al. · Journal of Medicinal Chemistry · 2019 · 15 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors

Zhou Hua, Meredeth A. McGowan, Kathryn Lipford et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 11 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14