Michael P. Hughes

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

Michael P. Hughes, M.R. Sawaya, David R. Boyer et al. · Science · 2018 · 470 citations · Full text

Protein Assembly, Subcellular Membraneless Assemblies, Biomolecular Structure Prediction +22

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation

E.L. Guenther, Qin Cao, Hamilton Trinh et al. · Nature Structural & Molecular Biology · 2018 · 264 citations

X-ray Crystallography, Crystal Structure, Protein Assembly +12

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle

Thomas O. Vogler, Joshua Wheeler, Éric Nguyen et al. · Nature · 2018 · 217 citations · Full text

Amyloid-like Myo-granules, Skeletal Muscle, Degenerative Pathology +6

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

David R. Boyer, Binsen Li, Chuanqi Sun et al. · Proceedings of the National Academy of Sciences · 2020 · 173 citations · Full text

Protein Assembly, Molecular Biology, Multiple Systems Atrophy +17

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta

Lin Jiang, Cong Liu, D.J. Leibly et al. · eLife · 2013 · 121 citations · Full text