Tests of the helix dipole model for stabilization of α-helices

Kevin Shoemaker, Peter S. Kim, Eunice J. York, +2

Nature

PhysicsProtein FoldingNatural SciencesMolecular BiologyMolecular Biophysics +3

Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Sauveur-Michel Maira, Sabina Pecchi, Alan Huang, +22

Molecular Cancer Therapeutics

PharmacotherapyDifferent Selectivity ProfileChemical BiologyPharmaceutical ChemistryTumor Biology +24

Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library

Ronald N. Zuckermann, Éric Martin, David C. Spellmeyer, +7

Journal of Medicinal Chemistry

Nature of the charged-group effect on the stability of the C-peptide helix.

Kevin Shoemaker, Peter S. Kim, David N. Brems, +5

Proceedings of the National Academy of Sciences

Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer

Matthew T. Burger, Sabina Pecchi, Allan S. Wagman, +27

ACS Medicinal Chemistry Letters

2,4-Bismorpholino 6-Heterocyclic PyrimidinesPi3 Kinase InhibitorOrally Bioavailable ClassGliomaPharmaceutical Chemistry +16

Further studies of the helix dipole model: Effects of a free α‐NH₃⁺ or α‐COO⁻ group on helix stability

Robert Fairman, Kevin Shoemaker, Eunice J. York, +2

Proteins Structure Function and Bioinformatics

Protein AssemblyMagnetic ResonanceMolecular BiologyPeptide ScienceAnalytical Ultracentrifugation +16

Substrate Specificity of the <i>Escherichia coli</i> Outer Membrane Protease OmpT

John D. McCarter, Daren Stephens, Kevin Shoemaker, +3

Journal of Bacteriology

Side‐chain interactions in the C‐peptide helix: Phe 8 His 12⁺

Kevin Shoemaker, Robert Fairman, David Schultz, +4

Biopolymers

Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor

Alexei S. Karpov, Payman Amiri, Cornelia Bellamacina, +23

ACS Medicinal Chemistry Letters

Drug TargetMolecular BiologyPharmacotherapyDibenzodiazepine Hit 1Chemical Biology +14

[27] Random mutagenesis of protein sequences using oligonucleotide cassettes

John F. Reidhaar-Olson, James U. Bowie, Richard Breyer, +7

Methods in enzymology on CD-ROM/Methods in enzymology

Oligonucleotide CassettesGeneticsOligonucleotideMolecular BiologyGenetic Engineering +3