Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid

Hiroto Hatakeyama, Hidetaka Akita, Kentaro Kogure, +7

Gene Therapy

Cancer TherapyNanomedicineCell-based Drug DeliveryEngineeringGene Delivery +5

Estrogen Regulates Hepcidin Expression via GPR30-BMP6-Dependent Signaling in Hepatocytes

Yasumasa Ikeda, Soichiro Tajima, Yuki Izawa‐Ishizawa, +5

PLoS ONE

Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice

Soichiro Tajima, Yasumasa Ikeda, Kaori Sawada, +10

American Journal of Physiology-Endocrinology and Metabolism

Metabolic DisorderIron MetabolismLipid PeroxidationRedox BiologyOxidative Stress +15

Iron Chelation by Deferoxamine Prevents Renal Interstitial Fibrosis in Mice with Unilateral Ureteral Obstruction

Yasumasa Ikeda, Iori Ozono, Soichiro Tajima, +8

PLoS ONE

Deferoxamine promotes angiogenesis via the activation of vascular endothelial cell function

Yasumasa Ikeda, Soichiro Tajima, Sumiko Yoshida, +7

Atherosclerosis

Endothelial Cell PathobiologyDevelopmental BiologyAngiogenesisEndothelial DysfunctionVascular Biology +4

Deletion of Hypoxia-Inducible Factor-1α in Adipocytes Enhances Glucagon-Like Peptide-1 Secretion and Reduces Adipose Tissue Inflammation

Yoshitaka Kihira, Mariko Miyake, Manami Hirata, +11

PLoS ONE

Metabolic DisorderImmunologyAhko MicePathologyCaloric Restriction +22

Formation of Heteromeric Kv2 Channels in Mammalian Brain Neurons

Yoshitaka Kihira, Tracey O. Hermanstyne, Hiroaki Misonou

Journal of Biological Chemistry

Smooth muscle cell-specific Hif-1α deficiency suppresses angiotensin II-induced vascular remodelling in mice

Masaki Imanishi, Shuhei Tomita, Keisuke Ishizawa, +7

Cardiovascular Research

Dietary iron restriction inhibits progression of diabetic nephropathy in<i>db/db</i>mice

Yasumasa Ikeda, Hideaki Enomoto, Soichiro Tajima, +6

American Journal of Physiology-Renal Physiology

NutritionIron MetabolismRenal InflammationDb/db Mouse ModelRedox Biology +15

Iron-induced skeletal muscle atrophy involves an Akt-forkhead box O3–E3 ubiquitin ligase-dependent pathway

Yasumasa Ikeda, Mizuki Imao, Akiho Satoh, +9

Journal of Trace Elements in Medicine and Biology

Muscle FunctionMolecular PhysiologyMuscle InjurySkeletal MuscleIron Metabolism +4