Ian Gurrell

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

M. Catarina Silva, Ghata Nandi, Sharon Tentarelli et al. · Nature Communications · 2020 · 158 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo

Darren J. Schofield, Lorraine Irving, Laura Calò et al. · Neurobiology of Disease · 2019 · 119 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Application of PBPK modelling in drug discovery and development at Pfizer

Hannah M. Jones, Maurice Dickins, Kuresh Youdim et al. · Xenobiotica · 2011 · 94 citations

Pharmacy, Pharmacokinetics, Pharmacology +8

Discovery of Clinical Candidate 4-[2-(5-Amino-1<i>H</i>-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-<i>N</i>-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na_V1.7

Nigel A. Swain, D. V. Batchelor, Serge Beaudoin et al. · Journal of Medicinal Chemistry · 2017 · 83 citations · Full text

Pharmacy, Clinical Pharmacokinetics, Pharmacology +17

Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti–transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity

Carl I. Webster, Jon P. Hatcher, Matthew Burrell et al. · Pain · 2016 · 69 citations · Full text

Pharmacy, Immunology, Medicinal Chemistry +17