Alfonso De Simone

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

Giuliana Fusco, Serene W. Chen, Philip T. F. Williamson et al. · Science · 2017 · 695 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

Atomic structure and hierarchical assembly of a cross-β amyloid fibril

Anthony W. P. Fitzpatrick, Galia T. Debelouchina, Marvin J. Bayro et al. · Proceedings of the National Academy of Sciences · 2013 · 563 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Release of High-Energy Water as an Essential Driving Force for the High-Affinity Binding of Cucurbit[<i>n</i>]urils

Frank Biedermann, Vanya D. Uzunova, Oren A. Scherman et al. · Journal of the American Chemical Society · 2012 · 553 citations

Pharmacy, Biophysics, Chemistry +17

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

Giuliana Fusco, Alfonso De Simone, Tata Gopinath et al. · Nature Communications · 2014 · 478 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Determination of Secondary Structure Populations in Disordered States of Proteins Using Nuclear Magnetic Resonance Chemical Shifts

Carlo Camilloni, Alfonso De Simone, Wim Vranken et al. · Biochemistry · 2012 · 384 citations

Life Sciences, Biochemistry, Biology +15