SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

Jiří Zahradník, Shir Marciano, Maya Shemesh, +15

Nature Microbiology

Vitro EvolutionViral EvolutionEngineeringMedicineAntiviral Drug Development +10

NEMO specifically recognizes K63‐linked poly‐ubiquitin chains through a new bipartite ubiquitin‐binding domain

Emmanuel Laplantine, E Fontan, Jeanne Chiaravalli, +5

The EMBO Journal

Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues

Nathaniel R. Kastan, Ksenia Gnedeva, Theresa Alisch, +9

Nature Communications

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential

Bjoern Meyer, Jeanne Chiaravalli, Stacy Gellenoncourt, +16

Nature Communications

SARS-CoV-2 RBD <i>in vitro</i> evolution follows contagious mutation spread, yet generates an able infection inhibitor

Jiří Zahradník, Shir Marciano, Maya Shemesh, +7

Vitro EvolutionAble Infection InhibitorViral PathogenesisImmunologyImmunodominance +16

Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine

Marion Plaze, David Attali, Matthieu Prot, +11

International Journal of Antimicrobial Agents

Human CellsMedicineImmunologyAntiviral Drug DevelopmentAntiviral Therapy +6

Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2

Cyril Planchais, I. Fernández, Timothée Bruel, +22

The Journal of Experimental Medicine

Adaptive Immune SystemHumoral ResponseImmunologyOmicron Ba.1Viral Structural Protein +15

Inhibition of NF-κB Activation by Peptides Targeting NF-κB Essential Modulator (NEMO) Oligomerization

Fabrice Agou, Gilles Courtois, Jeanne Chiaravalli, +5

Journal of Biological Chemistry

Immune RegulationImmunologyMolecular BiologyPeptide ScienceCellular Physiology +21

Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 omicron sub-lineages

Franck Touret, Émilie Giraud, Jérôme Bourret, +8

iScience

DARPin-Assisted Crystallography of the CC2-LZ Domain of NEMO Reveals a Coupling between Dimerization and Ubiquitin Binding

Olivera Grubisha, M. Kamińska, S. Duquerroy, +9

Journal of Molecular Biology

Ubiquitin BindingCc2-lz DomainCrystal StructureBiophysicsProtein X-ray Crystallography +6