Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Yingyue Zhou, Wilbur M. Song, Prabhakar S. Andhey, +22

Nature Medicine

Neurodegenerative DiseasesMolecular NeuroscienceAlzheimer's DiseaseSynaptic SignalingMedicine +11

Tissue Resident CCR2− and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury

Geetika Bajpai, Andrea Bredemeyer, Wenjun Li, +12

Circulation Research

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

Denis A. Mogilenko, Oleg Shpynov, Prabhakar S. Andhey, +15

Immunity

InflammationAutoimmune DiseaseAdaptive Immune SystemComprehensive ProfilingMedicine +10

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

Kyeongdae Kim, Dahee Shim, Jun Seong Lee, +20

Circulation Research

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure

Andrew L. Koenig, Irina Shchukina, Junedh Amrute, +11

Nature Cardiovascular Research

Heart FailureGeneticsCardiac Progenitor CellsTranscriptomics TechnologyTranscriptional Regulation +15

An Immunocompetent Mouse Model of Zika Virus Infection

Matthew J. Gorman, Elizabeth A. Caine, Konstantin Zaitsev, +21

Cell Host & Microbe

Zika Virus InfectionViral PathogenesisImmunologyVirologyVirus Transmission +2

Subsets of ILC3−ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues

Marina Cella, Ramya Gamini, Cristiane Sécca, +21

Nature Immunology

InflammationIlc3−ilc1-like CellsAutoimmune DiseaseMucosal ImmunologyInnate Immune System +8

Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

Jesse W. Williams, Konstantin Zaitsev, Ki-Wook Kim, +15

Nature Immunology

InflammationVascular DiseaseImmunologyMonocyte RecruitmentChronic Inflammation +9

Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures

Konstantin Zaitsev, Monika Bambousková, Amanda Swain, +1

Nature Communications

Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis

Michael T. Patterson, Maria Firulyova, Yingzheng Xu, +17

Nature Cardiovascular Research