Dec1 and Dec2 are regulators of the mammalian molecular clock

Sato Honma, Takeshi Kawamoto, Yumiko Takagi, +5

Nature

ChromatinTranscriptional RegulationSignal TransductionMolecular RegulationMolecular Biology +7

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

Yumiko Takagi, Toshiyuki Kobayashi, Masatoshi Shiono, +8

Oncogene

Protein FunctionSignal TransductionMolecular PhysiologyProtein ExpressionMedicine +9

Crown Ethers as Regulators of Enzymatic Reactions:  Enhanced Reaction Rate and Enantioselectivity in Lipase-Catalyzed Hydrolysis of 2-Cyano-1-methylethyl Acetate

Toshiyuki Itoh, Yumiko Takagi, Takako Murakami, +2

The Journal of Organic Chemistry

Crown EthersAsymmetric CatalysisNovel OrganocatalystsVarious Crown EthersEngineering +13

Thiacrown Ether Technology in Lipase-Catalyzed Reaction:  Scope and Limitation for Preparing Optically Active 3-Hydroxyalkanenitriles and Application to Insect Pheromone Synthesis

Toshiyuki Itoh, Koichi Mitsukura, Wipa Kanphai, +3

The Journal of Organic Chemistry

Thiacrown EtherEngineeringPropyl AcetateOrganic ChemistryChemistry +14

An efficient enantioselective total synthesis of antitumor lignans: synthesis of enantiomerically pure 4-hydroxyalkanenitriles via an enzymic reaction

Toshiyuki Itoh, Jun-ichi Chika, Yumiko Takagi, +1

The Journal of Organic Chemistry

Altmetric Attention ScoreOrganic ChemistryPharmaceutical ChemistryMedicinal ChemistryBiochemistry +14

Laccase-Catalyzed Reactions in Ionic Liquids for Green Sustainable Chemistry

Toshiyuki Itoh, Yumiko Takagi

ACS Sustainable Chemistry & Engineering

Abrogation of the interaction between osteopontin and αvβ3 integrin reduces tumor growth of human lung cancer cells in mice

Ri Cui, Fumiyuki Takahashi, Rina Ohashi, +9

Lung Cancer

Cancer Cell BiologyCell-matrix InteractionαVβ3 Integrin ReducesMatrix BiologyRadiation Oncology +5

Enhanced enantioselectivity of an enzymatic reaction by the sulfur functional group. A simple preparation of optically active .beta.-hydroxy nitriles using a lipase

Toshiyuki Itoh, Yumiko Takagi, Shigenori Nishiyama

The Journal of Organic Chemistry

Molecular SciencesEngineeringBiochemistryEnhanced EnantioselectivityNatural Sciences +12

Systematic Synthesis of Multifluorinated α,α-Difluoro-γ-lactones through Intramolecular Radical Cyclization

Toshiyuki Itoh, Kohei Sakabe, Kazutoshi Kudo, +5

The Journal of Organic Chemistry

Systematic SynthesisBioorganic ChemistryBiochemistryNatural SciencesFluorous Synthesis +10

Thiacrown ether as regulator of lipase-catalyzed trans-esterification in organic media: Practical optical resolution of allyl alcohols

Yumiko Takagi, Jun Teramoto, Hiroshi Kihara, +2

Tetrahedron Letters

Allyl AlcoholsPractical Optical ResolutionBiochemistryEngineeringNatural Sciences +10