Britta Handyside

Gene Therapy with BMN 270 Results in Therapeutic Levels of FVIII in Mice and Primates and Normalization of Bleeding in Hemophilic Mice

Stuart Bunting, Lening Zhang, Lin Xie et al. · Molecular Therapy · 2017 · 72 citations · Full text

Vector genome loss and epigenetic modifications mediate decline in transgene expression of AAV5 vectors produced in mammalian and insect cells

Britta Handyside, Ashrafali Mohamed Ismail, Lening Zhang et al. · Molecular Therapy · 2022 · 46 citations · Full text

Induction of ER Stress by an AAV5 BDD FVIII Construct Is Dependent on the Strength of the Hepatic-Specific Promoter

Sylvia Fong, Britta Handyside, Choong‐Ryoul Sihn et al. · Molecular Therapy — Methods & Clinical Development · 2020 · 42 citations · Full text

Hepatic-specific Promoter, Adeno-associated Virus 5, Immunology +18

Intracerebroventricular enzyme replacement therapy with β-galactosidase reverses brain pathologies due to GM1 gangliosidosis in mice

Joseph C. Chen, Amanda Luu, Nathan Wise et al. · Journal of Biological Chemistry · 2019 · 39 citations · Full text

Molecular analysis of AAV5-hFVIII-SQ vector-genome-processing kinetics in transduced mouse and nonhuman primate livers

Choong‐Ryoul Sihn, Britta Handyside, Su Liu et al. · Molecular Therapy — Methods & Clinical Development · 2021 · 31 citations · Full text