LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

Jian Luo, Zhengfeng Yang, Yu Ma, +16

Nature Medicine

Developmental BiologyBone ResorptionBone Morphogenic ProteinBone RemodelingOsteoarthritis +9

Dual base editor catalyzes both cytosine and adenine base conversions in human cells

Xiaohui Zhang, Biyun Zhu, Liang Chen, +23

Nature Biotechnology

Cellular EnzymologyBiochemistryAdenine Base ConversionsHuman CellsNatural Sciences +9

Genome-wide transcriptome profiling of homologous recombination DNA repair

Guang Peng, Curtis Chun-Jen Lin, Wei Mo, +12

Nature Communications

Genome InstabilityGeneticsDna ReplicationGenome-wide Transcriptome ProfilingChromosomal Rearrangement +2

Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization

Binghe Tan, Xiujuan Shi, Jie Zhang, +10

Cancer Research

Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Liang Chen, Biyun Zhu, Gaomeng Ru, +22

Nature Biotechnology

EngineeringGenome SurgeryGenetic EngineeringSynthetic BiologyDna Replication +8

Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer

Weiqiang Lü, Weiwei Yu, Jiacheng He, +18

EMBO Molecular Medicine

GPR116, an Adhesion G-Protein–Coupled Receptor, Promotes Breast Cancer Metastasis via the Gαq-p63RhoGEF-Rho GTPase Pathway

Xiaolong Tang, Rongrong Jin, Guojun Qu, +10

Cancer Research

Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2

Ying Wang, Jie Dong, Dali Li, +4

Stem Cells

LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells

Zhiying Yue, Zengjin Yuan, Li Zeng, +14

The FASEB Journal

Breast OncologyCancer Stem CellCancer BiologyMammary Gland DevelopmentTumor Biology +15

Dual Targeting of Bile Acid Receptor-1 (TGR5) and Farnesoid X Receptor (FXR) Prevents Estrogen-Dependent Bone Loss in Mice

Zhenxi Li, Jingping Huang, Fanhua Wang, +16

Journal of Bone and Mineral Research