Complex molecular genetic abnormalities involving three or more genetic mutations are important prognostic factors for acute myeloid leukemia

Satoshi Wakita, Hiroki Yamaguchi, Tomoyuki Ueki, +19

Leukemia

Hematological MalignancyChromatinMore Genetic MutationsMedicineGenetics +9

Risk Factors for Acute Kidney Injury and Chronic Kidney Disease following Allogeneic Hematopoietic Stem Cell Transplantation for Hematopoietic Malignancies

Masahiro Sakaguchi, Kazutaka Nakayama, Hiroki Yamaguchi, +18

Acta Haematologica

AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice

Hayato Tamai, Koichi Miyake, Hiroki Yamaguchi, +4

Blood

RCSD1-ABL1-positive B lymphoblastic leukemia is sensitive to dexamethasone and tyrosine kinase inhibitors and rapidly evolves clonally by chromosomal translocations

Koiti Inokuchi, Satoshi Wakita, Tsuneaki Hirakawa, +4

International Journal of Hematology

Hematological MalignancyChromatinGeneticsChromosomal TranslocationsKinase Inhibitors +4

Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study

Hayato Tamai, Hiroki Yamaguchi, Hiroyuki Hamaguchi, +25

International Journal of Hematology

Hematological MalignancyMedicineCo-operative Multicenter StudyMixed-phenotype Acute LeukemiaHematology +6

Resistance of MLL–AFF1-positive acute lymphoblastic leukemia to tumor necrosis factor-alpha is mediated by S100A6 upregulation

Hayato Tamai, Keisuke Miyake, Hiroki Yamaguchi, +4

Blood Cancer Journal

Mixed-phenotype Acute LeukemiaImmunologyCell DeathMixed-lineage LeukemiaS100a6 Expression +14

Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations

Tairo Ryotokuji, Hiroki Yamaguchi, Tatsuya Ueki, +23

Haematologica

Amlexanox Downregulates S100A6 to Sensitize <i>KMT2A/AFF1</i>-Positive Acute Lymphoblastic Leukemia to TNFα Treatment

Hayato Tamai, Hiroki Yamaguchi, Koichi Miyake, +7

Cancer Research

Full-length mutation search of the TP53 gene in acute myeloid leukemia has increased significance as a prognostic factor

Kazuki Terada, Hiroki Yamaguchi, Toshimitsu Ueki, +20

Annals of Hematology

Hematological MalignancyMedicineAcute Myeloid LeukemiaMixed-phenotype Acute LeukemiaHematology +10

Inhibition of S100A6 induces GVL effects in MLL/AF4-positive ALL in human PBMC-SCID mice

Hayato Tamai, Keisuke Miyake, Hiroki Yamaguchi, +3

Bone Marrow Transplantation

Knockout MouseMll/af4-positive AllAutoimmune DiseaseImmunologyAntiviral Response +5