Kyle Clagg

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)

F. Anthony Romero, Jeremy Murray, Kwong Wah Lai et al. · Journal of Medicinal Chemistry · 2017 · 131 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

A Benzyne Insertion Approach to Hetisine-Type Diterpenoid Alkaloids: Synthesis of Cossonidine (Davisine)

Kevin G. M. Kou, Jason J. Pflueger, Toshihiro Kiho et al. · Journal of the American Chemical Society · 2018 · 68 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +15

Data Science-Enabled Palladium-Catalyzed Enantioselective Aryl-Carbonylation of Sulfonimidamides

Lucy van Dijk, Brittany C. Haas, Ngiap‐Kie Lim et al. · Journal of the American Chemical Society · 2023 · 66 citations

Pharmacy, Chemistry, Medicinal Chemistry +16

Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036

Jie Xu, Samantha Grosslight, Sierra C. Nguyen et al. · Journal of the American Chemical Society · 2022 · 55 citations

Pharmacy, Chemistry, Medicinal Chemistry +17

Synthesis of Indole-2-carboxylate Derivatives via Palladium-Catalyzed Aerobic Amination of Aryl C–H Bonds

Kyle Clagg, Haiyun Hou, Adam B. Weinstein et al. · Organic Letters · 2016 · 43 citations

Natural Sciences, Chemistry, Catalysis +8