Stephen R. Brych

Effect of Ions on Agitation- and Temperature-Induced Aggregation Reactions of Antibodies

R. Matthew Fesinmeyer, Sabine Hogan, Atul Saluja et al. · Pharmaceutical Research · 2008 · 129 citations

Pharmacy, Biochemistry, Immunology +9

Characterization of antibody aggregation: Role of buried, unpaired cysteines in particle formation

Stephen R. Brych, Yatin R. Gokarn, Heather Hultgen et al. · Journal of Pharmaceutical Sciences · 2009 · 117 citations

Life Sciences, Biochemistry, Molecular Biology +16

Contributions of a disulfide bond to the structure, stability, and dimerization of human IgG1 antibody C_H3 domain

Arnold McAuley, Jaby Jacob, Carl G. Kolvenbach et al. · Protein Science · 2007 · 105 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Increased aggregation propensity of IgG2 subclass over IgG1: Role of conformational changes and covalent character in isolated aggregates

Heather Franey, Stephen R. Brych, Carl G. Kolvenbach et al. · Protein Science · 2010 · 82 citations · Full text

Pharmacy, Biochemistry, Molecular Biology +16

Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a β‐trefoil

Stephen R. Brych, Sachiko I. Blaber, Timothy M. Logan et al. · Protein Science · 2001 · 72 citations · Full text

Life Sciences, Evolutionary Biology, Molecular Biology +15