Thermodynamic and Structure Guided Design of Statin Based Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase

Ronald W. Sarver, Elizabeth Bills, Gary L. Bolton, +10

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryCardiovascular DiseaseStructure Guided DesignStatin Inhibitors +13

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors

Jeffrey A. Pfefferkorn, Yuntao Song, Kuai-Lin Sun, +27

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacology +3

Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase

Larry Bratton, Bruce J. Auerbach, Chulho Choi, +10

Bioorganic & Medicinal Chemistry

Medicinal ChemistryAldehyde DehydrogenaseAldo-keto ReductaseBiochemistryHmg-coa Reductase +10

Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, +13

Cancer Research

Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor δ agonists

Gary F. Filzen, Larry Bratton, Xue‐Min Cheng, +9

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologySelective BenzothiopheneMedicineMechanism Of ActionPharmacological Agent +6

Synthesis and structure-activity relationships for a series of substituted pyrrolidine NK1/NK2 receptor antagonists

Timothy P. Burkholder, Elizabeth M. Kudlacz, George D. Maynard, +19

Bioorganic & Medicinal Chemistry Letters

MedicineStructure-activity RelationshipsPharmacological AgentChemistryHeterocycle Chemistry +3

Synthesis of N-pivot lariat ethers and their metal ion complexation behavior

Larry Bratton, Bożena Strzelbicka, Richard A. Batsch

ARKIVOC

Synthesis and sar of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H1/tachykinin NK1 receptor antagonist activity

George D. Maynard, Larry Bratton, John M. Kane, +8

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryEngineeringMedicineDrug Discovery +6

Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring

Mark L. Boys, Feng Bian, James B. Kramer, +37

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAntifungal AgentDermal ScarringPotential UtilityMedicine +7

Biochemical Characterization of α-Ketooxadiazole Inhibitors of Elastases

Maciej Wieczorek, Albert Gyorkos, Lyle W. Spruce, +10

Archives of Biochemistry and Biophysics

BiochemistryMedicineα-Ketooxadiazole InhibitorsPharmacologyEnzymatic Modification +3