Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity

Fei Duan, Jorge Duitama, Sahar Al Seesi, +10

The Journal of Experimental Medicine

Structural dissimilarity from self drives neoepitope escape from immune tolerance

Jason R. Devlin, Jesus A. Alonso, Cory M. Ayres, +7

Nature Chemical Biology

Molecular ImmunologyImmune ToleranceSystems BiologyAutoimmune DiseasePathogenesis +8

Improving T Cell Receptor On-Target Specificity via Structure-Guided Design

Lance M. Hellman, Kendra C. Foley, Nishant K. Singh, +9

Molecular Therapy

Peptide Modulation of Class I Major Histocompatibility Complex Protein Molecular Flexibility and the Implications for Immune Recognition*

William F. Hawse, Brian E. Gloor, Cory M. Ayres, +3

Journal of Biological Chemistry

HistocompatibilityHla ImmunogeneticsImmunologyMolecular BiologyAntigen Processing +16

Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility

Cory M. Ayres, Esam T. Abualrous, A.G. Bailey, +6

Frontiers in Immunology

Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner

Angela R. Smith, Jesus A. Alonso, Cory M. Ayres, +3

Proceedings of the National Academy of Sciences

Geometrical characterization of T cell receptor binding modes reveals class‐specific binding to maximize access to antigen

Nishant K. Singh, Esam T. Abualrous, Cory M. Ayres, +4

Proteins Structure Function and Bioinformatics

Differential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity

Cory M. Ayres, Daniel R. Scott, Steven A. Corcelli, +1

Scientific Reports

A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces

Timothy P. Riley, Cory M. Ayres, Lance M. Hellman, +8

Protein Engineering Design and Selection

Structural and physical features that distinguish tumor-controlling from inactive cancer neoepitopes

Jean M. F. Custódio, Cory M. Ayres, Tatiana J. Rosales, +6

Proceedings of the National Academy of Sciences

ImmunologyPathologyRare Protective NeoepitopesAntigen ProcessingImmunotherapy +19