Lukáš Hroch

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment

Lukáš Hroch, Patrick Guest, Ondřej Benek et al. · Bioorganic & Medicinal Chemistry · 2016 · 58 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Science +12

A Direct Interaction Between Mitochondrial Proteins and Amyloid-β Peptide and its Significance for the Progression and Treatment of Alzheimer’s Disease

Ondřej Benek, Laura Aitken, Lukáš Hroch et al. · Current Medicinal Chemistry · 2015 · 40 citations · Full text

Amyloid-β Peptide, Cell Death, Mitochondrial Biology +24

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget‐Directed Ligands for the Treatment of Alzheimer's Disease

Ondřej Benek, Ondřej Soukup, Markéta Pasdiorová et al. · ChemMedChem · 2015 · 36 citations

Novel Benzothiazole-Based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer’s Disease Treatment

Laura Aitken, Ondřej Benek, Brogan E. McKelvie et al. · Molecules · 2019 · 36 citations · Full text

Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer’s disease treatment

Lukáš Hroch, Ondřej Benek, Patrick Guest et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 34 citations

Alzheimer's Disease, Potential Abad/17β-hsd10 Modulators, Biochemistry +8