Howard Roark

Synthesis and Characterization of Novel Bi- and Tricyclic <font>α</font> -Amino Acids

Matthew R. Johnson, Jolicia F. Gauuan, Cheng Guo et al. · Synthetic Communications · 2011 · 19 citations

Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors

Mark S. Plummer, Joseph A. Cornicelli, Howard Roark et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 18 citations · Full text

Biochemistry, Osteoarthritis Pain Model, Medicine +10

Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: Optimization studies and demonstration of in vivo efficacy

Mark S. Plummer, Joseph A. Cornicelli, Howard Roark et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 15 citations · Full text

Osteoarthritis Pain Model, Medicine, Drug Discovery +9

The preparation of optically active α-amino 4H-[1,2,4]oxadiazol-5-ones from optically active α-amino acids

John E. Mangette, Matthew R. Johnson, Van‐Duc Le et al. · Tetrahedron · 2009 · 15 citations

Combinatorial Chemistry, Bioorganic Chemistry, Engineering +5