Concepedia

John E. Mangette

JE

Statistics

Publications

13

Citations

410

H-Index

11

Active since

1994

Affiliations

CHDI Foundation(Current)

Albany Molecular Research (United States)

Evotec (Germany)

Karolinska Institutet

IRBM Science Park

John E. Mangette is an author at CHDI Foundation specializing in organic chemistry, chemistry, and natural sciences.

Top concepts

Publications per year

1994–2022

13

Publications

13

Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease

Roland W. Bürli, Christopher A. Luckhurst, Omar Aziz et al. · Journal of Medicinal Chemistry · 2013 · 147 citations · Full text

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Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand

Longbin Liu, Michael E. Prime, Matt R. Lee et al. · Journal of Medicinal Chemistry · 2020 · 55 citations

[<sup>11</sup>C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins

Longbin Liu, Peter Johnson, Michael E. Prime et al. · Journal of Medicinal Chemistry · 2021 · 31 citations

Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington’s Disease Pathology

Natsuko Macabuag, William Esmieu, Perla Breccia et al. · Journal of Medicinal Chemistry · 2022 · 29 citations · Full text

Design and Evaluation of [<sup>18</sup>F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates

Longbin Liu, Peter Johnson, Michael E. Prime et al. · Journal of Medicinal Chemistry · 2022 · 25 citations

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