Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

Johanna K. Hansen, Alina Baum, Kristen E. Pascal, +44

Science

VaccinationHumanized MiceSpike ProteinVaccine TargetViral Pathogenesis +13

Structure of the mechanically activated ion channel Piezo1

Kei Saotome, Swetha E. Murthy, Jennifer M. Kefauver, +3

Nature

EngineeringBioelectronicsIon ChannelsElectrophysiologyPiezoelectric Material +5

Crystal structure of the epithelial calcium channel TRPV6

Kei Saotome, Appu K. Singh, Maria V. Yelshanskaya, +1

Nature

Crystal StructureMolecular PhysiologyProtein X-ray CrystallographyMolecular BiologyStructural Biology +5

The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies

Richard Copin, Alina Baum, Elzbieta Wloga, +34

Cell

Opening of the human epithelial calcium channel TRPV6

Luke L. McGoldrick, Appu K. Singh, Kei Saotome, +4

Nature

Signal TransductionMolecular PhysiologyCell TraffickingPhysiologyIntracellular Trafficking +5

Cryo-EM structure of the mechanically activated ion channel OSCA1.2

Sebastian Jojoa-Cruz, Kei Saotome, Swetha E. Murthy, +4

eLife

Proteinlipid InteractionEngineeringMolecular BiologyMa Ion ChannelsCellular Physiology +16

Structure of the human volume regulated anion channel

Jennifer M. Kefauver, Kei Saotome, Adrienne E. Dubin, +10

eLife

Human VolumeHomomeric ChannelMolecular BiologyCytoskeletonCellular Physiology +20

Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB

Appu K. Singh, Kei Saotome, Luke L. McGoldrick, +1

Nature Communications

Structures of the otopetrin proton channels Otop1 and Otop3

Kei Saotome, Bochuan Teng, Che Chun Tsui, +6

Nature Structural & Molecular Biology

Proton TransferProton-coupled Electron TransferReceptor (Biochemistry)Molecular Biology

Swapping of transmembrane domains in the epithelial calcium channel TRPV6

Appu K. Singh, Kei Saotome, Alexander I. Sobolevsky

Scientific Reports