Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

John T. Chang, V. Palanivel, Ichiko Kinjyo, +12

Science

Unequal PartitioningAutoimmune DiseaseCell DivisionAdaptive Immune ResponsesMedicine +13

SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation

Ichiko Kinjyo, Toshikatsu Hanada, Kyoko Inagaki‐Ohara, +6

Immunity

Macrophage BiologyInflammationCytokineImmunologyAutoimmunity +5

Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits <i>Janus</i> tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain

Atsuo T. Sasaki, Hideo Yasukawa, Asuka Suzuki, +6

Genes to Cells

Involvement of Suppressor of Cytokine Signaling-3 as a Mediator of the Inhibitory Effects of IL-10 on Lipopolysaccharide-Induced Macrophage Activation

Chiara Berlato, Marco A. Cassatella, Ichiko Kinjyo, +3

The Journal of Immunology

Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells Partially Through STAT3-Dependent Mechanism

Takeru Yoshimura, Atsunobu Takeda, Shinjiro Hamano, +5

The Journal of Immunology

Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production

Takatoshi Chinen, Takafumi Yoshida, Ichiko Kinjyo, +5

Oncogene

InflammationFibrosisSignal TransductionHepatologySignaling Pathway +9

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1

Ichiko Kinjyo, Hiromasa Inoue, Shinjiro Hamano, +8

The Journal of Experimental Medicine

Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway.

Akihiko Yoshimura, Masatoshi Ichihara, Ichiko Kinjyo, +6

The EMBO Journal

Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division

John T. Chang, Maria L. Ciocca, Ichiko Kinjyo, +15

Immunity

Transcription Factor T-betUnequal PartitioningCell DivisionAsymmetric Proteasome SegregationAdaptive Immune System +7

Real-time tracking of cell cycle progression during CD8+ effector and memory T-cell differentiation

Ichiko Kinjyo, Jim Qin, Sioh-Yang Tan, +11

Nature Communications