FGF21 gene therapy as treatment for obesity and insulin resistance

Verónica Jiménez, Claudia Jambrina, Estefanía Casana, +21

EMBO Molecular Medicine

Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance

Ivet Elias, Sylvie Franckhauser, Tura Ferré, +9

Diabetes

Metabolic DisorderImmunologyInsulin SignalingOxidative StressObesity +17

Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice

Sylvie Franckhauser, Ivet Elias, Victoria Rotter Sopasakis, +7

Diabetologia

InflammationMetabolic SyndromeCytokineLiver PhysiologyPhysiology +10

New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance

Ivet Elias, Sylvie Franckhauser, Fátima Bosch

Adipocyte

Metabolic DisorderImmunologyNew InsightsMetabolic RemodelingInsulin Signaling +22

Adipose Overexpression of Phospho<i>enol</i>pyruvate Carboxykinase Leads to High Susceptibility to Diet-Induced Insulin Resistance and Obesity

Sylvie Franckhauser, Sergio Muñoz, Ivet Elias, +2

Diabetes

Metabolic DisorderTransgenic MiceAdipose OverexpressionInsulin SignalingObesity +17

In Vivo Adeno-Associated Viral Vector–Mediated Genetic Engineering of White and Brown Adipose Tissue in Adult Mice

Verónica Jiménez, Sergio Muñoz, Estefanía Casana, +7

Diabetes

Metabolic RemodelingInsulin SignalingObesityMetabolic SyndromeCell Signaling +18

BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue

Jenny Hoffmann, John Grünberg, Christopher Church, +7

Cell Reports

NutritionImmunologyInsulin SignalingBmp4 VectorsOxidative Stress +20

ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance

Ivet Elias, Tura Ferré, Laia Vilà, +9

Diabetes

Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs

Maria Luisa Jaén, Laia Vilà, Ivet Elias, +14

Molecular Therapy — Methods & Clinical Development

Diabetes ManagementLong-term EfficacyInsulin ManagementDiabetes8-Year Follow-up +6

Chronically increased glucose uptake by adipose tissue leads to lactate production and improved insulin sensitivity rather than obesity in the mouse

Sergio Muñoz, Sylvie Franckhauser, Ivet Elias, +8

Diabetologia

ObesityNutritionMetabolic SyndromeImproved Insulin SensitivityEnergy Homeostasis +12