Melanie Nyuydzefe

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

Alexandra Zanin‐Zhorov, Jonathan M. Weiss, Melanie Nyuydzefe et al. · Proceedings of the National Academy of Sciences · 2014 · 244 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +24

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Ryan Flynn, Katelyn Paz, Jing Du et al. · Blood · 2016 · 209 citations · Full text

Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10

Alexandra Zanin‐Zhorov, Jonathan M. Weiss, Alissa Trzeciak et al. · The Journal of Immunology · 2017 · 88 citations · Full text

ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis

Christina Nalkurthi, Wayne A. Schroder, Michelle Melino et al. · JHEP Reports · 2021 · 69 citations · Full text

ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings

Jonathan M. Weiss, Wei Chen, Melanie Nyuydzefe et al. · Science Signaling · 2016 · 55 citations · Full text

Regulatory T, Signal Transduction, Autoimmune Disease +15