Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Ryan Flynn, Katelyn Paz, Jing Du, +23

Blood

Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10

Alexandra Zanin‐Zhorov, Jonathan M. Weiss, Alissa Trzeciak, +22

The Journal of Immunology

Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

Yating Wang, Alissa Trzeciak, Waleska Saitz Rojas, +8

Cell Metabolism

Metabolic Adaptation SupportsPhysiologyAutophagyMetabolic RegulationMetabolic Remodeling +4

In situ neutrophil efferocytosis shapes T cell immunity to influenza infection

Kihong Lim, Tae‐Hyoun Kim, Alissa Trzeciak, +6

Nature Immunology

InflammationInnate Immune SystemImmunologyAutoimmunityT Cell Immunity +4

ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings

Jonathan M. Weiss, Wei Chen, Melanie Nyuydzefe, +7

Science Signaling

Regulatory TSignal TransductionAutoimmune DiseaseRock2 ActivityImmune Cell Development +13

Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus

Jiqiang Lin, Hernandez Moura Silva, Alissa Trzeciak, +4

Nature Communications

Long-Term Microgliosis Driven by Acute Systemic Inflammation

Alissa Trzeciak, Yelena V. Lerman, Tae‐Hyoun Kim, +4

The Journal of Immunology

Transgenic mice overexpressing <scp>CD</scp>109 in the epidermis display decreased inflammation and granulation tissue and improved collagen architecture during wound healing

Joshua Vorstenbosch, Corrie L. Gallant‐Behm, Alissa Trzeciak, +3

Wound Repair and Regeneration

EngineeringImmune RegulationImmunologyCd109 Transgenic MiceDermatology +19

Brief Report: CD109 Overexpression Ameliorates Skin Fibrosis in a Mouse Model of Bleomycin‐Induced Scleroderma

Joshua Vorstenbosch, Hanan Alajmi, Sebastian Winocour, +3

Arthritis & Rheumatism

<scp>CD</scp>109, a novel <scp>TGF</scp>‐<i>β</i> antagonist, decreases fibrotic responses in a hypoxic wound model

Sebastian Winocour, Joshua Vorstenbosch, Alissa Trzeciak, +2

Experimental Dermatology

Tissue EngineeringScar ManagementEngineeringImmunologyCd109 Transgenic Mice +23