Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus

Fumihiko Matsuda, Euy Kyun Shin, Hitoshi Nagaoka, +9

Nature Genetics

ImmunogeneticsGeneticsImmunologyMolecular GeneticsImmunoglobulin E +3

Somatic Hypermutation in the Heavy Chain Locus Correlates with Transcription

Yosho Fukita, Heinz Jacobs, Klaus Rajewsky

Immunity

Transcriptional RegulationSomatic VariantSomatic HypermutationSomatic Cell GeneticsMedicine +9

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

Linda Bross, Yosho Fukita, Fraser McBlane, +3

Immunity

Genome InstabilityDna Double-strand BreaksNatural SciencesGeneticsMolecular Biology +4

Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype.

E K Shin, Fumihiko Matsuda, Hitoshi Nagaoka, +5

The EMBO Journal

Autoantibody-related Variable SegmentsHaplotype DeterminationLinkage DisequilibriumAutoimmune DiseaseAutoantibody Production +8

Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice

Heinz Jacobs, Yosho Fukita, Gijsbertus T. J. van der Horst, +11

The Journal of Experimental Medicine

The human S mu bp-2, a DNA-binding protein specific to the single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region

Yosho Fukita, Tatsunobu-Ryushin Mizuta, Michio Shirozu, +3

Journal of Biological Chemistry

ChromatinImmunogeneticsDna-binding Protein SpecificS MuNatural Sciences +13

Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences

Tatsunobu-Ryushin Mizuta, Yosho Fukita, Takashi Miyoshi, +2

Nucleic Acids Research

Recent Translocation of Variable and Diversity Segments of the Human Immunoglobulin Heavy Chain from Chromosome 14 to Chromosomes 15 and 16

Hitoshi Nagaoka, Kazuo Ozawa, Fumihiko Matsuda, +11

Genomics

ImmunogeneticsRecent TranslocationCytogeneticsGeneticsImmunodeficiencies +11

Comparison and evolution of human immunoglobulin VH segments located in the 3' 0.8-megabase region. Evidence for unidirectional transfer of segmental gene sequences.

Makoto Haino, Hidenori Hayashida, Takashi Miyata, +7

Journal of Biological Chemistry

Structural analysis of the human VH locus using nonrepetitive intergenic probes and repetitive sequence probes. Evidence for recent reshuffling.

Ryusuke Matsumura, Fumihiko Matsuda, Hitoshi Nagaoka, +5

The Journal of Immunology

Vh LocusGeneticsHuman PolymorphismMolecular BiologyMolecular Genetics +17