Clare Buckeridge

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor

David A. Griffith, David J. Edmonds, Jean‐Philippe Fortin et al. · Journal of Medicinal Chemistry · 2022 · 153 citations · Full text

Medicine, Endocrinology, Pharmacology +17

Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial

Aditi R. Saxena, Donal Gorman, Ryan M. Esquejo et al. · Nature Medicine · 2021 · 142 citations

Medicine, Endocrinology, Pharmacology +10

Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition

William P. Esler, Gregory J. Tesz, Marc K. Hellerstein et al. · Science Translational Medicine · 2019 · 63 citations

Life Sciences, Biochemistry, Dermatology +14

A Phase Ib First-In-Patient Study Assessing the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ponsegromab in Participants with Cancer and Cachexia

Jeffrey Crawford, Roberto A. Calle, Susie M. Collins et al. · Clinical Cancer Research · 2023 · 59 citations · Full text

Medicine, Oncology, Pharmacology +12

De novo lipogenesis is essential for platelet production in humans

Kenneth L. Kelly, William J. Reagan, Gabriele E. Sonnenberg et al. · Nature Metabolism · 2020 · 48 citations

Life Sciences, Biochemistry, Hematology +9