Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein

Chang Hoon Lee, Mark Melchers, Hongsheng Wang, +13

The Journal of Experimental Medicine

Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function

Dirk Eggink, Mark Melchers, Manfred Wuhrer, +12

Virology

Virus StructureProtein FoldingHuman RetrovirusComplex N-glycansImmunology +10

Immunosilencing a Highly Immunogenic Protein Trimerization Domain

Kwinten Sliepen, Thijs van Montfort, Mark Melchers, +2

Journal of Biological Chemistry

Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4+ T-lymphocytes

Martijn J. Stax, Thijs van Montfort, Richard R. Sprenger, +7

Virology

Blocks Dendritic CellSeminal PlasmaHuman RetrovirusImmunologyAntiviral Response +8

Targeting HIV-1 Envelope Glycoprotein Trimers to B Cells by Using APRIL Improves Antibody Responses

Mark Melchers, Ilja Bontjer, Tommy Tong, +11

Journal of Virology

Trimeric EnvAntibody ResponsesHuman RetrovirusImmunologyB Cells +13

The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion

Rogier W. Sanders, Eelco van Anken, Alexei A Nabatov, +10

Retrovirology

A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells

Mark Melchers, Katie Matthews, Robert P. de Vries, +8

Retrovirology

Stabilized HIV-1 Envelope Glycoprotein Trimers Lacking the V1V2 Domain, Obtained by Virus Evolution

Ilja Bontjer, Mark Melchers, Dirk Eggink, +4

Journal of Biological Chemistry

Viral ReplicationV1v2 DomainImmunologyMolecular BiologyImmunodominance +18

A Chimeric HIV-1 Envelope Glycoprotein Trimer with an Embedded Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Domain Induces Enhanced Antibody and T Cell Responses

Thijs van Montfort, Mark Melchers, Gözde Isik, +8

Journal of Biological Chemistry

The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis

Martine Ossevoort, Arnaud Zaldumbide, Aartjan J.W. te Velthuis, +4

Molecular Immunology

ImmunologyVirologyVirus GeneViral Structural ProteinGene Expression +5