José-Ignacio Andrés

Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

Dieter Ory, Sofie Celen, Rik Gijsbers et al. · Journal of Nuclear Medicine · 2016 · 87 citations · Full text

Pyrido[4,3-<i>e</i>][1,2,4]triazolo[4,3-<i>a</i>]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors

Frederik Rombouts, Gary Tresadern, Peter Buijnsters et al. · ACS Medicinal Chemistry Letters · 2015 · 56 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Science +14

Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

José-Ignacio Andrés, Jesús Alcázar, José M. Cid et al. · Journal of Medicinal Chemistry · 2012 · 53 citations · Full text

Allosteric Binding Site, Peptide Science, New Series +20

Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement

Peter Buijnsters, Meri De Angelis, Xavier Langlois et al. · ACS Medicinal Chemistry Letters · 2014 · 51 citations · Full text

Drug Target, Neurochemical Biomarkers, Clinical Neuroscience +22

Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging

José-Ignacio Andrés, Meri De Angelis, Jesús Alcázar et al. · Journal of Medicinal Chemistry · 2011 · 43 citations · Full text