Robert R. Donatelli

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation <i>in vitro</i> and sensitize tumors to doxorubicin <i>in vivo</i>

Holly K. Koblish, Shuyuan Zhao, Carol F. Franks et al. · Molecular Cancer Therapeutics · 2006 · 162 citations · Full text

P53 Interaction, Chemoprevention Strategy, P53 Complex +18

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

Carl L. Manthey, Dana L. Johnson, Carl R. Illig et al. · Molecular Cancer Therapeutics · 2009 · 107 citations

Solid Tumors, Immunology, Cancer Biology +17

Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors

Mark J. Wall, Jinsheng Chen, Sanath K. Meegalla et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 47 citations · Full text

Novel 3,4,6-Substituted 2-Quinolones, Combinatorial Chemistry, Medicinal Chemistry +9

Pyrido[2,3-<i>d</i>]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors

Hui Huang, Daniel A. Hutta, James M. Rinker et al. · Journal of Medicinal Chemistry · 2009 · 40 citations · Full text

Immunology, Pharmacotherapy, Pharmaceutical Chemistry +17

Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor

Michael P. Winters, Carl Crysler, Nalin L. Subasinghe et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 35 citations · Full text

Medicinal Chemistry, Cxcr2 Receptor, Biochemistry +11