Hillary P. Handler

Antisense oligonucleotide–mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles

Jillian Friedrich, Holly Kordasiewicz, Brennon O’Callaghan et al. · JCI Insight · 2018 · 130 citations · Full text

Knockout Mouse, Neurodegenerative Diseases, Magnetic Resonance Spectroscopy +15

Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1

Ravi Chopra, David D. Bushart, John P Cooper et al. · Human Molecular Genetics · 2020 · 27 citations · Full text

Neurotransmission, Social Sciences, Ion Channel Transcripts +16

Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1

Stephanie L. Coffin, Mark A. Durham, Larissa Nitschke et al. · Neuron · 2022 · 27 citations · Full text

Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment

Brennon O’Callaghan, Bente Hofstra, Hillary P. Handler et al. · Molecular Therapy — Nucleic Acids · 2020 · 22 citations · Full text

Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice

Juao-Guilherme Rosa, Katherine Hamel, Carrie Sheeler et al. · Cells · 2022 · 15 citations · Full text