Francisco Fierro

The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences.

Francisco Fierro, José Luis Barredo, Begoña Díez et al. · Proceedings of the National Academy of Sciences · 1995 · 189 citations · Full text

Genetics, Penicillin Gene Cluster, Bacteriology +17

Filamentous fungi from extreme environments as a promising source of novel bioactive secondary metabolites

Renato Chávez, Francisco Fierro, Ramón O. García-Rico et al. · Frontiers in Microbiology · 2015 · 105 citations · Full text

Engineering, Promising Source, Molecular Biology +17

Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence

Francisco Fierro, Eduardo José Nepomuceno Montenegro, Santiago Gutiérrez · Applied Microbiology and Biotechnology · 1996 · 90 citations

Penicillin Biosynthesis Show, Antimicrobial Resistance Gene, Health Sciences +14

Resolution of four large chromosomes in penicillin-producing filamentous fungi: the penicillin gene cluster is located on chromosome II (9.6 Mb) in Penicillium notatum and chromosome 1 (10.4 Mb) in Penicillium chrysogenum

Francisco Fierro, Santiago Gutiérrez, Juan F. Martı́n · Molecular and General Genetics MGG · 1993 · 86 citations

Biology, Genetics, Penicillin Gene Cluster +7

Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum

Santiago Gutiérrez, Javier Velasco, Ana T. Marcos et al. · Applied Microbiology and Biotechnology · 1997 · 79 citations

Biology, Plant Molecular Biology, Biosynthesis +10