Michele Johnstone

Avibactam and Class C β-Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for Resistance

Sagar Lahiri, Michele Johnstone, Philip L. Ross et al. · Antimicrobial Agents and Chemotherapy · 2014 · 182 citations · Full text

Avibactam Bound, Antimicrobial Chemotherapy, Class C β-Lactamases +22

Characterization of <i>Escherichia coli</i> NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3

Richard A. Alm, Michele Johnstone, Sushmita D. Lahiri · Journal of Antimicrobial Chemotherapy · 2015 · 175 citations · Full text

Translating slow-binding inhibition kinetics into cellular and in vivo effects

Grant K. Walkup, Zhiping You, Philip L. Ross et al. · Nature Chemical Biology · 2015 · 148 citations · Full text

Signal Transduction, Biochemistry, Cell Signaling +13

Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in <i>Pseudomonas aeruginosa</i> strains containing derepressed AmpC

Sushmita D. Lahiri, Grant K. Walkup, James Whiteaker et al. · Journal of Antimicrobial Chemotherapy · 2015 · 124 citations · Full text

<i>In Vitro</i> Antibacterial Activity of AZD0914, a New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious Gram-Negative, and Atypical Bacteria

Michael D. Huband, Patricia A. Bradford, Linda G. Otterson et al. · Antimicrobial Agents and Chemotherapy · 2014 · 73 citations · Full text

Molecular Biology, Antimicrobial Chemotherapy, Drug Resistance +23