Jean‐François Bonfanti

A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

Suzanne J. F. Kaptein, Olivia Goethals, Dominik Kiemel et al. · Nature · 2021 · 181 citations · Full text

Ns3–ns4b Interaction, Immunology, Antiviral Drug Development +4

Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

Olivia Goethals, Suzanne J. F. Kaptein, Bart Kesteleyn et al. · Nature · 2023 · 106 citations · Full text

Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate. 2. Discovery of a Morpholinopropylaminobenzimidazole Derivative (TMC353121)

Jean‐François Bonfanti, Christophe Meyer, Frédéric Doublet et al. · Journal of Medicinal Chemistry · 2008 · 97 citations

Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein

Dirk Roymans, Hendrik L. De Bondt, Éric Arnoult et al. · Proceedings of the National Academy of Sciences · 2009 · 88 citations · Full text

Viral Replication, Protein Assembly, Synthetic Virology +20

Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model

Wieslawa Olszewska, Gabriela Ispas, Corinna Schnoeller et al. · European Respiratory Journal · 2010 · 55 citations · Full text