Osamu Okazaki

Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite

Miho Kazui, Yumi Nishiya, Tomoko Ishizuka et al. · Drug Metabolism and Disposition · 2009 · 821 citations

Medicine, Biochemistry, Pharmacology +17

Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy

Akinori Kimura, Haruhito Harada, Jeong-Euy Park et al. · Nature Genetics · 1997 · 577 citations

Medicine, Genetics, Molecular Genetics +12

Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation

Ken Okumura, Masaharu Akao, Tetsuro Yoshida et al. · New England Journal of Medicine · 2020 · 335 citations

Medicine, Pharmacology, Pharmacotherapy +17

Nighttime Blood Pressure Phenotype and Cardiovascular Prognosis

Kazuomi Kario, Satoshi Hoshide, Hiroyuki Mizuno et al. · Circulation · 2020 · 298 citations · Full text

Medicine, Cardiology, Clinical Cardiology +15

A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

Shintaro Nakayama, Ryo Atsumi, Hideo Takakusa et al. · Drug Metabolism and Disposition · 2009 · 248 citations

Pharmacy, Pharmacology, Toxicology +17