Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells

Changjie Wu, Junfang Lyu, Eun Ju Yang, +3

Nature Communications

RSPO2–LGR5 signaling has tumour-suppressive activity in colorectal cancer

Changjie Wu, Sunquan Qiu, Liting Lu, +12

Nature Communications

Tumor BiologySignaling PathwayColorectal CancerRspo2–lgr5 SignalingTumor Suppressor +4

Cancer-associated fibroblasts-derived exosomal miR-17-5p promotes colorectal cancer aggressive phenotype by initiating a RUNX3/MYC/TGF-β1 positive feedback loop

Yue Zhang, Shanci Wang, Qiuhua Lai, +10

Cancer Letters

OncologyMedicineCancer Cell BiologyColorectal CancerCancer Biology +9

Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth

Junfang Lyu, Eun Ju Yang, Sarah A. Head, +11

Cancer Letters

AngiogenesisEndothelial CellsOxysterolMedicineTumor Growth +7

A preventive maintenance model for leased equipment subject to internal degradation and external shock damage

Xiaojun Zhou, Changjie Wu, Yanting Li, +1

Reliability Engineering & System Safety

Internal DegradationEngineeringMaintenance PolicyCivil EngineeringPredictive Maintenance +8

Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics

Junfang Lyu, Eun Ju Yang, Baoyuan Zhang, +7

Nature Communications

METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer

Kangyue Sun, Lu Chen, Yiwen Li, +15

Cell Death and Disease

CTCF promotes colorectal cancer cell proliferation and chemotherapy resistance to 5-FU via the P53-Hedgehog axis

Qiuhua Lai, Qingyuan Li, Chengcheng He, +13

Aging

Tumor BiologyChemotherapy ResistanceCtcf RegulationMedicinePathology +12

LIMK1 m6A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation

Lu Chen, Kangyue Sun, Wenjie Qin, +9

Cancer Letters

Systems BiologyLimk1 M6a-rna MethylationMedicineColorectal CancerStress Granule Formation +5

Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

Baoyuan Zhang, Junfang Lyu, Eun Ju Yang, +8

Acta Pharmaceutica Sinica B