Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains

Kiyoto Kamagata, Saori Kanbayashi, Masaya Honda, +5

Scientific Reports

One-Dimensional Sliding of p53 Along DNA Is Accelerated in the Presence of Ca2+ or Mg2+ at Millimolar Concentrations

Agato Murata, Yuji Ito, Risa Kashima, +8

Journal of Molecular Biology

ChromatinGenome InstabilityNatural SciencesMillimolar ConcentrationsDna Replication +6

High Free-Energy Barrier of 1D Diffusion Along DNA by Architectural DNA-Binding Proteins

Kiyoto Kamagata, Eriko Mano, Kana Ouchi, +2

Journal of Molecular Biology

ChromatinDna NanotechnologyHigh Free-energy BarrierProtein FoldingMedicine +8

The Disordered Linker in p53 Participates in Nonspecific Binding to and One-Dimensional Sliding along DNA Revealed by Single-Molecule Fluorescence Measurements

Dwiky Rendra Graha Subekti, Agato Murata, Yuji Itoh, +5

Biochemistry

Molecular BiologyOne-dimensional SlidingSingle Molecule BiophysicsP53 ParticipatesSingle Molecule +14

One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain

Agato Murata, Yuji Itoh, Eriko Mano, +5

Biophysical Journal

Tumor BiologyDisordered C-terminal DomainMedicineTumor Suppressor P53Computational Biology +7

Characterization of design grammar of peptides for regulating liquid droplets and aggregates of FUS

Kiyoto Kamagata, Rika Chiba, Nanako Iwaki, +7

Scientific Reports

Molecular principles of recruitment and dynamics of guest proteins in liquid droplets

Kiyoto Kamagata, Nanako Iwaki, Milan Kumar Hazra, +11

Scientific Reports

Structure-dependent recruitment and diffusion of guest proteins in liquid droplets of FUS

Kiyoto Kamagata, Nanako Iwaki, Saori Kanbayashi, +5

Scientific Reports

Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53

Kiyoto Kamagata, Eriko Mano, Yuji Itoh, +6

Scientific Reports

Protein AssemblyStructural BioinformaticsMolecular BiologyPeptide ScienceBiological Computing +23

Single-molecule characterization of target search dynamics of DNA-binding proteins in DNA-condensed droplets

Kiyoto Kamagata, Ryo Kusano, Saori Kanbayashi, +2

Nucleic Acids Research

Dna NanotechnologyDna-binding ProteinSingle-molecule CharacterizationProtein FoldingNatural Sciences +11